Crossing the Blood-Brain Barrier With Engineered Natural Nanoparticles: A Dock-&-Transcytose Approach for Deep Parenchymal Delivery of ASO, siRNA, & Protein Cargos
- Presenting the NNP Trinity platform, a structure-prediction-driven approach that combines an NSM membrane engineering scaffold, AI-guided design of protein assembly, and a validated 3D bioreactor process for scalable, clinical-grade production of cell-derived natural nanoparticles
- Exploring the B-NNP brain shuttle, a dock-and-transcytose dual-targeting design in which Transferrin Receptor 1 drives receptor-mediated transcytosis across the blood-brain barrier while a second motif anchors the particle to a diseased-brain glycoprotein, enabling deep parenchymal delivery rather than perivascular accumulation
- Outlining applied oligonucleotide delivery with in vivo data on ASO and siRNA cargo loaded into B-NNP, including amyloid-beta reduction in a 5XFAD Alzheimer’s model after systemic IV dosing, with extension to additional CNS targets